Paul Isaacs' Blog

Autism from the inside

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The Root/Trajectory Of Autism Is A Diverse “Fruit Salad”

Brain Lobe 2Right hemisphere Functions

  • numerical computation (exact calculation, numerical comparison, estimation)
  • language: intonation/accentuation, prosody, pragmatic, contextual


If some one has an agnosia (perceptual loss) on this side of the brain this is called Social-Emotional Agnosia (not reading “facial expressions”, tone of and being literal) this tends to fit the profile with people with Asperger’s Syndrome. One is using the the left side of the brain (logic, literal thinking to get meaning).

So the Brain is Using The Left Hemisphere To Decode Information Because Of The Neglect.


Left hemisphere Functions

  • numerical computation (exact calculation, numerical comparison, estimation)
  • left hemisphere only: direct fact retrieval
  • language: grammar/vocabulary, literal


If someone has a agnosia (perceptual loss) on this side they may have an aphasia (language processing disorder) and process before typical interpretation (even literal) information so they loss the words (they become sounds), and they may have visual agnosias (face blindness, meaning blindness, object blindness) so they will not pick up body language this way and may rely on overt gesture and overt tone to get  “meaning” (using the right side of the brain to compensate for the left). less literal and less logical in their processing this could be someone with Autism.

So The Brain Is Using The Right Hemisphere To Decode Information Because Of The Neglect.




This could apply to people on the spectrum who have had and recognise brain injury as apart of their autism profile and how they have developed in many areas of functioning. From a personal perspective this article is very informative.

As a person who has left hemisphere brain injury (as apart of my autism), language processing disorder (aphasia) and visual agnosia this is I feel a step in the right direction.

Other Trajectories that Affect Development 

Paul… for some its brain injury… for some its immune dysfunction… for some its a neuronal migration disorder… for some its being prem… for some its hypo-connectivity… for some its hyper-connectivity.”

Brain Injury

Immune Dysfunction Syndrome

Neuronal Migration Disorder

Premature Syndrome 

Hypo connectivity Syndrome 

Hyper connectivity Syndrome

Fetal Alcohol Syndrome

Prenatal Smoking

Placental Abruption (Lack of Oxygen)

Vacuum-Assisted Delivery 



and many more

Donna Williams

Autism & It’s Trajectories Are Not “One Thing” They Are A “Fruit Salad” Unique In Origin 

Other diverse factors exist in how a person is on the autism spectrum and my own are as diverse and person-centered as another person’s trajectory. It has it’s own “Fruit Salad”.

Donna points out it isn’t just one defining factor but many many different ones and it’s important to not only acknowledge this but to also understand it is a reality for someone too and factors they bring with them. There could be a whole mixture of different factors that contribute to someone being on the autism spectrum.

In other words not only is “autism” not one thing but also the trajectory defining origins/factors aren’t one thing thing either.



Paul Isaacs 2014

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Reflective Thinking – My Father’s Glass Is Half Full – Is Yours?


My Father has a form of Leukemia called CLL with P53 gene deletion he has always reminded positive during his journey 

Dad With Cake

“Two and half years ago l was told by consultant l had months to live without a bone marrow transplant.”

“I was in hospital for 2 months got fungal pneumonia that nearly finished me off. I am nobody special a working class bloke. My experience with death has made me very spiritual people that know me may be surprised..but that experience has changed me forever.”

Paul Isaacs  2014

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Donna Williams – The Importance Of Recognising Gut, Metabolic and Auto-Immune Disorders in Autism Fruit Salads

Donna Williams 26 photo


PAUL ISAACS: What in your view is the importance in understanding people on the spectrum who have very specific gut, metabolic and autoimmune disorders (as part of their fruit salad) like yourself?

DONNA WILLIAMS: More recent studies have been finding that around 30-50% of those diagnosed with classical autism have different gut, immune, metabolic disorders. Where any child is failing to gain weight, is not growing, showing signs associated with malnutrition, bowel issues, allergy symptoms, behaviors indicating possible neuropathic pain, headaches, migraine, unexplained fever or signs of autonomic dysfunction then gut, immune, metabolic disorders should be considered and checked out.

Neuro-immune dysfunction can present as autism but once the health issues are addressed on an ongoing basis the child has a change to restore some neurological equilibrium which may put development back on track for them.

Every person with autism deserves the opportunity to reach their fullest potential. For those with addressable health issues, addressing these may be a big part of that.

For those without addressable health disorders this may mean helping that person to stretch their abilities where possible, adapting to that person’s disabilities or teaching them to communicate or advocate about their differences.

It is essential we do not project any one size fits all health reality onto all people with autism. It is as inhumane and wasteful to project health issues onto those who don’t have them as it is to ignore the health issues of those who do have these through fobbing everything off as ‘that’s just part of their autism’.


Thanks Donna for your insight and wisdom 🙂


Paul Isaacs  2014


The Brain Of Someone With Autism – Dr Manuel Casanova

Dr Casanova

Dr Casanova


I have a lot of respect for this gentleman, his work is very much to do with the questions that many people ask about the brain of someone with Autism the what’s? and the whys? and the hows? In his research Manuel Casanova has pursued to answer those questions in detail with many different cases studies into under and over connectivity in the brain to how the brain grows, is it genetic? is it acquired? a mix? What else? The endless possibilities are open to be explored but I would like to point out to you that Manuel has a deep care and kindness for people on the Autism spectrum and their personhoods. 🙂


This is to with sensory perceptual issues within Autism and brain connectivity, information processing, motion control, agnosias, aphasias, apraxias, learning difficulties, learning disabilities etc. I find this very interesting because it’s giving an inside perspective of what is making someone with Autism think, feel and process the world differently.



I like the work that Manuel is doing with care, dedication, empowerment and understanding for others on the spectrum, their loved ones and more. 🙂 Taking the time and effort to do this reflects what I have just said above and it also shows that care that he has for folks on the spectrum.



Thanks for Manuel. 🙂

Paul Isaacs  2014


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Autism & A Difficult Birth – Cerebral Hypoxia, Silent Stroke, Middle & Posterior Arteries, Agnosias & Apraxias

Baby 1987 2


Note – This is a personal experiences of the trajectory of my Autism

I certainly had Cerebral Hypoxia as apart of a difficult birth I was born a month premature and through Caesarian Section . The Cerebral Arteries also had a part to play in this also.

Middle Cerebral Artery

Middle Cerebral Artery Syndrome

Which resulted in the following –

Posterior Cerebral Artery

Stroke Not not all these symptoms apply to me

Peripheral territory (Cortical branches) Not not all these symptoms apply to me

  • Homonymous hemianopia (often upper quadrantic): Calcarine cortex or optic radiation nearby.
  • Bilateral homonymous hemianopia, cortical blindness, awareness or denial of blindness; tactile naming, achromatopia (color blindness), failure to see to-and-fro movements, inability to perceive objects not centrally located, apraxia of ocular movements, inability to count or enumerate objects, tendency to run into things that the patient sees and tries to avoid: Bilateral occipital lobe with possibly the parietal lobe involved.
  • Verbal dyslexia without agraphia, color anomia: Dominant calcarine lesion and posterior part of corpus callosum.
  • Memory defect: Hippocampal lesion bilaterally or on the dominant side only.
  • Topographic disorientation and prosopagnosia: Usually with lesions of nondominant, calcarine, and lingual gyrus.
  • Simultanagnosia, hemivisual neglect: Dominant visual cortex, contralateral hemisphere.
  • Unformed visual hallucinations, peduncular hallucinosis, metamorphopsia, teleopsia, illusory visual spread, palinopsia, distortion of outlines, central photophobia: Calcarine cortex.
  • Complex hallucinations: Usually nondominant hemisphere.


Due to a silent stroke within the womb which is to do with

Additional injury to the left hemisphere to the such as

and the rest such as Social Social-Emotional Agnosia, Alexithymia for example where genetics.


It is important to know the trajectory and the why’s and the hows? of how someone has Autism, all this being said I will not let this DEFINE my PERSONHOOD but it does continue to explain why a process and communicate in a particular way. 🙂

Paul Isaacs 2014



6 Months

Me at 6 Months Old With My Teddy



The Autism spectrum is a diverse spectrum of different profiles or as Donna Williams puts it “Fruit Salads” and different profiles means different presentations – I myself was diagnosed with Autism in 2010 and through recent interesting and fascinating conversations with Donna here is why I have an Autie Profile.


Copyright D.Williams from her Blog Differences between Aspergers and Autism ‘fruit salads’?

Fruit Salad Analogy Donna Williams

Fruit Salad Analogy Copyright D.Williams

  • higher degrees and severity of gutimmunemetabolic disorders, epilepsy and genetic anomalies impacting health systems – This is related to the family and history of cancer of both sides of my family including a recognised gene deletion 

  • mood, anxiety, compulsive disorders commonly observed since infancy – This is in my book “Living Through The Haze” in my early years I was showing signs of these issues from pre-school onwards

  • commonly amazing balance but commonly hypotonia

  • simultagnosia/meaning blindness rather than just scotopic sensitivity – Visual fragmentation and “seeing without meaning” is specifically to do with both simultagnosia, context blindness and semantic agnosia

  • verbal agnosia/meaning deafness – I have problem with filtering words with meaning they revert back sounds the larger the chunks of information

  • verbal communication impairments (aphasia, oral dyspraxia, verbal agnosia and associated echolalia and commonly secondary Selective Mutism)- “losing words within me”, having problems with articulation, patterning, themeing and feeling my own langauge (before interpartive language), reading information without meaning, echolalia and when speech was gained

  • higher severity of LD/Dyslexia/agnosias – Yes this relates to understanding/processing information

  • tendency toward OCD/Tourettes, also higher rate of Schizotypal PD, DPD is common and tends to be more severe – Yes developed OCD aged 12, tic disorder and throat clearing age 8, Schizotypal and Borderline PDs

  • higher tendency to Exposure Anxiety more than AvPD – Exposure Anxiety in Childhood/Teenage Years and  and Early Adulthood

  • higher tendency toward dissociative states (dissociation, derealisation, depersonalisation) – Yes this relates to me

  • poetry by those with autism as opposed to AS commonly indicates those with autism can have high levels of introspection, insight – Yes this does relate to me

  • ADHD extremely common co-occurrence – Hyperactivity as a child


Donna Williams Analogy does expand on the true diversity of Autism and all it’s different presentations I hope this helps others as much as it has helped me. 

Paul Isaacs 2014

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Donna Williams Fruit Salad Analogy- How it Has Helped – Autism and Asperger Differences


My Video on the differences on Autism & Asperger’s Syndrome (I’m an Autie). Donna Williams has helped me so much over the years using Donna Williams Fruit Salad  Analogy . 🙂 This could also help you sort out your “Fruit Salad” too. 😉

Thanks Donna! 🙂





Fruit Salad Analogy Copyright D.Wiliams

Fruit Salad Analogy Copyright D.Williams



Paul Isaacs 2014